Orally Bioavailable Peptides and/or Peptide Therapeutics for Modulating Intracellular Targets

A top five pharmaceutical company with a history of successful academic collaborations, wishes to identify novel methods that allow for the discovery or design of orally bioavailable peptides and/or peptides that can access intracellular targets through passive permeation, endocytosis or via transporters.

Approaches of Interest

• Peptides designed to be intrinsically permeable/orally bioavailable through rational design (e.g., cyclisation, incorporation of non-natural amino acids, etc), next generation conjugation or other innovative approaches
• Design of ...