Seeking Synthetic Methods for Chemo- and Site-selective Bioconjugation in Proteins

Asahi Kasei Pharma, a global pharmaceutical company, is seeking chemical conjugation methods for N- or C-terminal specific protein modifications. In addition, the team is also interested in synthetic methods for chemo-selective and site-selective bioconjugation, including intermediate-site selective (e.g. Lysine- specific) bioconjugation.

Approaches of Interest:

• Ideally, submissions should include experimental data with the name of the model protein, reaction site and/or residue, conversion rate, and selectivity
• Methods that produce high protein yields ...