Cutting-edge Technologies to Discover Cryptic Pockets and Their Modulation

A global pharmaceutical company is seeking novel technologies that enable efficient and effective discovery of protein drug targets with cryptic pockets. Additionally, the team is also interested in ligand discovery strategies to target cryptic pockets.

Approaches of Interest:

• Technologies should identify or predict the cryptic pocket itself, with enzymes being of highest interest
• Both wet-based and dry-based approaches to discover cryptic pockets with ligandable/druggable pockets are of interest. Dry-based approaches should show feasibility and reliability...