Seeking Protein Engineering Approaches for Conditionally-activated Therapeutics

A top five pharmaceutical company wishes to identify protein engineering research and technologies that support the development of therapeutics with bi/multi-specific conditional activity. Our client is particularly interested in technologies which achieve conditional activation (e.g., by one of the approaches outlined below) which can be applied across multiple therapeutics and clinical indications.

Approaches of Interest:

• Activation by specific pH, proteases, small molecule binding or ligand binding
• Structural occlusion mechanisms i.e. engagement of a...